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Cardiovascular disease is the number one killer worldwide. Cardiac remodeling results from many cardiac
diseases and is often a transition to heart failure. Although epidemiological and clinical studies indicate beneficial effects of antioxidants in reducing heart disease and its associated morta…
Experimental 所以 evidence has suggested that adventitial fibroblasts may migrate into neointima of arteries after ballooninjury in various animal models. However, the molecular mechanism responsible for promoting the migration of vascularadventitial fibroblasts has not been well understood. In this s…
Dr Yuesheng HuangDr Yuesheng Huang,MD,PhD,thedirector and professor of surgery,Institute of Burn Research,Southwestern Hospital and Director ofthe State Key Laboratory 寻找更多 of Trauma,
P – CV -61@ ISP -02 -0795 -060216 Involvement of calcium – sensing receptor in ischemia/ reperfusion – induced rat cardiomyocyte apoptosis Wei – hua Zhang, Bo Wu, Dong – mei Gong , Ya – jun Zhao, Quan – feng Li, Li Zhang, Bao – feng Yang, Chang – qing Xu
(Department of Phathophysiology,
selleck抑制剂 Departmen…
MD2 PEDF(pigment epithelial-derived factor)is a potent inhibitor of VEGF-induced increases in vascular permeability and growth.However,the molecular mechanism of PEDFs action is unknown.The goal of this study was to test whether inhibition of the MAP(mitogen-activated protein)kinase pathway is in…
The present study aims to determine the role of mitogen-activated protein kinases(MAPKs)in EDAHB-mediated photodynamic therapy(EDAHB-PDT)-induced apoptosis of the A549 cells.EDAHB-PDT was found to induce proteolytic cleavage of procaspase-9 and-3 in A549 cells.
论文一重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白对神经病理性疼痛大鼠行为学的影响 目的观察益赛普对神经病理性疼痛大鼠行为学的影响。方法成年雄性SD大鼠32只随机分为假手术组+NS组、CCI+NS组、CCI+0.4mg/kg益赛普组和CCI+0.8mg/kg益赛普组,于术后即刻开始至取材点每天给予皮下注射益赛普或生理盐水。于术前1d,术后1d、3d、7d测定机械性痛觉阈值(MWT)、热痛觉阈值(TWL)和运动功能评分。结果与假手术组相比,CCI组机械痛和热痛阈值在术后各时间点都明显下降(P<0.05)。益赛普组在术后各时间点机械痛和热痛阈值较CCI组都明显升高(P<0.05),且高剂量组较低剂量组有明显升高(P<0.05),与CCI组相比,益赛普组TNF-α免疫活性明显降低(P<0.05),与低剂量组相比,高剂量益赛普组TNF-α免疫活性明显降低(P<0.05),与CCI组相比,益赛普组TNF-αmRNA表达明显降低(P<0.05),与低剂量组相比,高剂量益赛普组TNF-αmRNA表达明显降低(P<0.